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The science behind CellFoam™ technology
Veterinary medicine continues to evolve through the development of practical technologies designed for use in established clinical procedures. Across the field, there is a growing need for site-specific solutions applied directly at the point of treatment. This need is particularly evident in areas such as periodontal care, surgical bleeding control, and urinary incontinence management, where localized approaches offer key advantages in clinical outcomes. BioChange developed CellFoam™, a proprietary, three-dimensional scaffold technology to answer those needs. CellFoam™-based products are designed to provide temporary physical support at the treatment site and to biodegrade over time. The specific form, intended purpose, and method of application vary by product.
This article describes of CellFoam™ characteristics and the variety of application across BioChange's veterinary product portfolio.
Why does the management of tissue defects remain challenging? Disease, trauma, and surgery may result in tissue defects that vary in size, shape, location, and clinical complexity. The management of these defects may require appropriate site preparation, stabilization, and postoperative care.
Successful healing may be more difficult when:
- The tissue defect is too large to heal predictably on its own.
- The local tissue architecture has been disrupted.
- The treatment site lacks physical support or stability.
- Bleeding or fluid movement interferes with stabilization.
- The damaged area is difficult to access or treat.
- Patient- or site-specific factors may affect the healing process.
In appropriate cases, a temporary scaffold may provide physical support at the treatment site during the healing period.
What is a protein-based scaffold?
A protein-based scaffold is a three-dimensional structure designed to temporarily occupy or support a treatment site. Porous gelatin scaffolds are widely investigated and used as biomaterials because their physical properties can be adapted for different medical applications.1
An effective scaffold should provide:
- A defined three-dimensional structure.
- A porous architecture that permits the movement of biological fluids.
- Biocompatibility with the surrounding tissues.
- Adaptability to irregularly shaped defects.
- Appropriate physical stability for the intended period of use.
- A biodegradation profile appropriate for the intended use.
The scaffold can be permanent or degradable. Permanent scaffolds increase the risk of developing long-term side effects, while degradable scaffoldsprovide temporary physical support and gradually biodegrade over time, they are challenged with degradation rate that needs to be aligned with the tissue repair process.
CellFoam™: a three-dimensional biodegradable scaffold technology
CellFoam™ is BioChange's proprietary, enzymatically cross-linked gelatin scaffold technology. Its three-dimensional porous structure is designed in a unique foam structure, that provides temporary physical-mechanical support at the site of application.
Depending on the product, the scaffold is designed to adapt to the treatment site and biodegrade over time. The technology can be produced in different forms—including dry foam scaffolds, miniature foams, injectable foam, and powder-based formulations—for specific veterinary applications.
Key characteristics of CellFoam™ technology
Three-dimensional porous architecture in a unique foam structure
Based on a familiar material
CellFoam™ is made from cross-linked gelatin derived from collagen, one of the primary structural components of the body's extracellular matrix.
Adaptable to different applications
The technology can be manufactured in different shapes, sizes, and formats to meet the requirements of various clinical procedures.
Designed for direct application
CellFoam™-based products are applied directly to the treatment site, enabling targeted use during surgical and non-surgical procedures.
Biodegradable
The scaffold is designed to provide temporary support and to biodegrade over time.
Designed for veterinary clinical use
Each BioChange product is designed for use by trained veterinary professionals in accordance with its specific instructions for use.
CellFoam™ applications in animal health
An adjunct for closed periodontal pockets' therapy
Non-surgical periodontal treatment includes thorough cleaning and debridement of the tooth and root surfaces to remove plaque, calculus, and contaminated material.
MicroFoam™ is a mini-foam CellFoam™ scaffold developed for placement in periodontal pockets following thorough debridement.
Its small dimensions allow it to be placed in an appropriately prepared periodontal pocket without creating an open surgical flap. Once positioned, MicroFoam™ occupies the available space and provides a temporary three-dimensional scaffold to support tissue.
MicroFoam™ is intended for use as an adjunct to established non-surgical periodontal treatment, following thorough debridement and in accordance with the product's Instructions for Use.
To learn more, watch MicroFoam webinars here.
A scaffold for periodontal defects and oral health
Periodontal disease can result in the loss of soft tissue and supporting alveolar bone around the teeth. Conventional periodontal treatment focuses on removing plaque, calculus, inflamed tissue, and bacterial contamination.
Thorough debridement and appropriate infection control are essential components of periodontal treatment. ReGum™ Vet is a three-dimensional, biodegradable scaffold designed for placement in periodontal and oral tissue defects. After hydration, the scaffold can be adapted to the treated area and positioned within the defect. It is intended to fill and provide temporary physical support at the treatment site
Subject to the cleared indication and Instructions for Use applicable in the relevant market, ReGum™ Vet is intended for filling and augmentation of boney and periodontal defects in clinical settings. Evidences of ReGum™ Vet being used in studies and case-studies were shown in a vast range of procedures involving:
- Periodontal defects and Infrabony defects.
- Furcation defects.
- Selected mandibular defects.
- Selected ridge-preservation procedures.
Potential future uses of ReGum™ Vet may be of the following:
- Periodontal defects involving loss of supporting alveolar bone.
- Extraction sockets.
- Oral cyst cavities.
- Oral soft-tissue defects.
ReGum™ Vet is intended to be used in conjunction with appropriate periodontal debridement, infection control, surgical technique, and postoperative care. A prospective split-mouth clinical study in dogs with naturally occurring periodontitis reported improvements in clinical periodontal parameters and radiographic alveolar bone level when the tested scaffold was used in an open periodontal therapy procedure.2
To learn more, watch ReGum webinar here.
A topical hemostatic powder
Local hemostasis is an important component of surgical, dental, and trauma-related procedures. Gelatin-based topical hemostatic materials are established as a class of materials used to assist with local bleeding control.3
vitaloc™ is a powder-based hemostatic medical device designed for direct application to the bleeding site. Upon contact with blood, the formulation forms a localized physical matrix that assists in the control of bleeding.
Its principal mode of action is mechanical-physical and localized to the bleeding area. The resulting matrix adapts to the application site and acts as a mechanical barrier to assist hemostasis.
Subject to the cleared indication and Instructions for Use applicable in the relevant market, vitaloc is intended for controlling of medium to sever bleeding. Preclinical studies and veterinary case-studies and users feedback, reflects its successful use in:
- Dental and oral surgery.
- Soft-tissue surgery.
- Selected surgical bleeding sites.
Other potential applications may include:
- Selected trauma-related bleeding sites.
- Difficult-to-access or irregular bleeding surfaces.
vitaloc™ provides veterinarians with a biodegradable, locally applied option to assist in controlling bleeding at an appropriately prepared treatment site.
To learn more, watch vitaloc case studies here.
A urethral bulking agent for female dogs
Urinary incontinence can significantly affect the well-being of dogs and the quality of life of their owners. Some patients do not respond adequately to medication, cannot tolerate long-term pharmacological treatment, or require an additional therapeutic option.
VetFoam™ is an injectable, biodegradable urethral bulking agent intended for the management of urinary sphincter mechanism incompetence in female dogs.
VetFoam™ is administered under endoscopic guidance into the proximal urethral submucosa by a trained veterinarian. It creates localized tissue bulking to assist urethral coaptation and gradually biodegrades over time.
A prospective study of 15 female dogs with urinary sphincter mechanism incompetence evaluated the safety and efficacy of VetFoam™ as a urethral bulking agent and reported a mean continence duration of 11.1 months after the first injection.4 Individual response and duration of effect may vary.
To learn more, watch VetFoam webinar here.
One technology, multiple veterinary solutions
Although the products address different clinical needs, they share a common technological principle: a three-dimensional, gelatin-based material designed for localized application and gradual biodegradation. This platform-based approach allows BioChange to adapt the properties and delivery format of its technology to the requirements of each clinical application.
| Product | Primary application | Product format | Clinical purpose |
| ReGum™ Vet | Periodontal and oral defects | Three-dimensional scaffold | Fills and provides temporary physical support within oral defects |
| MicroFoam™ | Small periodontal defects/pockets | Miniature scaffold | Adjunctive scaffold following thorough non-surgical debridement |
| vitaloc™ | Surgical or traumatic bleeding | Hemostatic powder | Assists localized bleeding control through a mechanical-physical mode of action |
| VetFoam™ | Urinary incontinence in female dogs | Injectable foam | Assists urethral coaptation through localized bulking |
Designed for the realities of veterinary practice
Innovative technology creates meaningful value only when it can be used effectively in routine clinical care. BioChange's veterinary products are therefore designed with practical implementation in mind. Depending on the product and indication, potential advantages include:
- Direct and targeted application.
- Integration into familiar clinical procedures.
- Adaptation to irregular anatomical sites.
- Biodegradable; designed to biodegrade over time without leaving a permanent implant.
- Multiple forms for different treatment needs.
- Formats suitable for selected minimally invasive procedures.
- Applications for both general and specialist veterinary practice.
Appropriate patient selection, diagnosis, treatment-site preparation, product placement, and follow-up are essential. Each product must be used only by trained veterinary professionals and in accordance with its Instructions for Use.
Expanding practical options in veterinary care
CellFoam™ technology provides a versatile platform for medical devices designed to perform specific physical-mechanical roles at the treatment site. Through its versatile, three-dimensional gelatin-based platform, BioChange is developing practical solutions for veterinary dentistry, surgery, hemostasis, and urology needs. The portfolio is built around one central idea: adapting a three-dimensional, biodegradable gelatin technology to specific veterinary clinical applications.
BioChange's commitment
BioChange is a medical technology company developing medical devices for veterinary applications. Its veterinary portfolio is supported by multidisciplinary expertise in biomaterials, clinical research, product development, and medical-device manufacturing. Through CellFoam™ technology, BioChange aims to provide veterinarians with practical medical devices designed for use in defined veterinary procedures.
Professional tools and resources
Veterinary professionals can access supporting materials designed to facilitate the appropriate use of BioChange products, including:
- Product information sheets.
- Instructions for use.
- Clinical case reports.
- Application and procedure guides.
- Educational videos.
- Scientific publications.
- Webinars and professional training materials.
